Context-Dependent T-Box Transcription Factor Family: From Biology To Targeted Therapy

Authors

Siwen Li
Xiangyuan Luo
Mengyu Sun
Yijun Wang
Zerui Zhang
Junqing Jiang
Dian Hu
Jiaqian Zhang
Zhangfan Wu
Yufei Wang
Wenjie Huang
Limin Xia

Publication Date

7-4-2024

Journal

Cell Communication and Signaling

Abstract

T-BOX factors belong to an evolutionarily conserved family of transcription factors. T-BOX factors not only play key roles in growth and development but are also involved in immunity, cancer initiation, and progression. Moreover, the same T-BOX molecule exhibits different or even opposite effects in various developmental processes and tumor microenvironments. Understanding the multiple roles of context-dependent T-BOX factors in malignancies is vital for uncovering the potential of T-BOX-targeted cancer therapy. We summarize the physiological roles of T-BOX factors in different developmental processes and their pathological roles observed when their expression is dysregulated. We also discuss their regulatory roles in tumor immune microenvironment (TIME) and the newly arising questions that remain unresolved. This review will help in systematically and comprehensively understanding the vital role of the T-BOX transcription factor family in tumor physiology, pathology, and immunity. The intention is to provide valuable information to support the development of T-BOX-targeted therapy.

Keywords

Humans, Neoplasms, Tumor Microenvironment, Animals, T-Box Domain Proteins, Molecular Targeted Therapy

Comments

Associated Data

DOI

10.1186/s12964-024-01719-2

PMID

38965548

PMCID

PMC11225425

PubMedCentral® Posted Date

July 2024

PubMedCentral® Full Text Version

Post-Print