Identifying Sleep-Related Factors Associated with Cognitive Function in a Hispanics/Latinos Cohort: A Dual Random Forest Approach

Authors

Li Xiaojin
Cui Licong
Wang Fei
Paul E Schulz
Guo-Qiang Zhang

Publication Date

1-1-2021

Journal

AMIA Summits on Translational Science Proceedings

Abstract

Disordered sleep is associated with poor cognitive function and cognitive decline. However, little is known regarding the association of sleep-related factors with cognitive function in underrepresented cohorts such as the Hispanic/Latino population. Leveraging the National Sleep Research Resource, one of the most comprehensive collections of sleep studies, we identified a Hispanic/Latino cohort of 1,031 lower cognitive function cases and 2,062 normal controls. We developed a novel dual random forest (DRF) approach to discriminate cases against controls for estimating the potential impact of sleep-related variables related to the decline of cognitive function. Several important sleep-related factors were identified which may be associated with cognitive function in the Hispanics/Latinos cohort, such as heart rate, sleep duration, trouble falling asleep, and apnea/hypopnea index, which are consistent with existing research findings. Our DRF approach is effective in validating the association between disordered sleep and cognitive decline in this unique minority population.

Keywords

Cognition, Cognitive Dysfunction, Hispanic or Latino, Humans, Sleep, Sleep Wake Disorders

PMID

35308908

PMCID

PMC8861662

PubMedCentral® Posted Date

2-21-2022

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes