Faculty, Staff and Student Publications
Publication Date
8-1-2023
Journal
Human Vaccines & Immunotherapeutics
Abstract
A growing literature supports a protective association between vaccines targeting an array of pathogens (e.g., influenza, pneumococcus, herpes zoster) and the risk of Alzheimer disease (AD). This article discusses the potential underlying mechanisms for this apparent protective effect of immunizations against infectious pathogens on the risk of AD; explores the basic and pharmacoepidemiologic evidence for this association, with particular attention paid to important methodological variations among the epidemiologic studies; and reviews the remaining uncertainties regarding the effects of anti-pathogen vaccines on Alzheimer disease and all-cause dementia, with recommendations for future directions to address those uncertainties.
Keywords
Humans, Alzheimer Disease, Vaccination, Influenza Vaccines, Immunization, Influenza, Human, Diphtheria-Tetanus-acellular Pertussis Vaccines, Vaccines, influenza vaccines, diphtheria-tetanus-acellular pertussis vaccines, pneumococcal vaccines, innate immunity, trained immunity, Alzheimer disease, dementia, neuroimmunomodulation, pharmacoepidemiology
DOI
10.1080/21645515.2023.2216625
PMID
37291109
PMCID
PMC10332212
PubMedCentral® Posted Date
6-8-2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Community Health and Preventive Medicine Commons, Data Science Commons, Influenza Humans Commons, Pharmacy and Pharmaceutical Sciences Commons
