Metabolic Imaging Using Hyperpolarization for Assessment of Premalignancy

Authors

Shivanand Pudakalakatti
Priyank Raj
Travis C Salzillo
José S Enriquez
Dontrey Bourgeois
Prasanta Dutta
Mark Titus
Shayan Shams
Priya Bhosale
Michael Kim
Florencia McAllister
Pratip K Bhattacharya

Publication Date

1-1-2022

Journal

Methods in Molecular Biology

Abstract

There is an unmet need for noninvasive surrogate markers that can help identify premalignant lesions across different tumor types. Here we describe the methodology and technical details of protocols employed for in vivo

Keywords

Carbon Isotopes, Humans, Magnetic Resonance Imaging, Precancerous Conditions, Pyruvic Acid, Hyperpolarization, Metabolic imaging, MRI, 13C, HP-MR, Premalignancy, Early detection, Assessment of preventive responses

DOI

10.1007/978-1-0716-2014-4_12

PMID

34993946

PMCID

PMC9352438

PubMedCentral® Posted Date

8-4-2022

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes