Faculty, Staff and Student Publications
Language
English
Publication Date
3-4-2025
Journal
Briefings in Bioinformatics
DOI
10.1093/bib/bbaf145
PMID
40188496
PMCID
PMC11972630
PubMedCentral® Posted Date
4-6-2025
PubMedCentral® Full Text Version
Post-print
Abstract
To advance the development of fusion protein-targeting therapeutics, it is crucial to understand how patients with fusion oncoproteins have been treated and what small molecules have been studied. To fill this gap, we developed FusionPub, a knowledgebase of the therapeutic landscape of human fusion genes. We searched PubMed abstracts for 107K human fusion genes with 14K drugs. We also searched PubMed abstracts for 18K human fusion proteins, considering all gene synonyms of individual partner genes with 14K drugs. After manual curation, we found 17 342 records from 9623 PubMed abstracts. For these fusion genes and drugs, we provide a summary sentence of their relationship using the generative AI, details of the drugs, clinical trial records, common drug records from patient treatment history, etc. FusionPub will be a valuable and unique resource providing knowledge of the development of fusion gene targeting therapeutics.
Keywords
Humans, Oncogene Proteins, Fusion, Databases, Genetic, Knowledge Bases, Neoplasms, fusion gene, drug, therapeutics, PubMed, ClinicalTrials.gov
Published Open-Access
yes
Recommended Citation
Kumar, Himansu; Adegunlehin, Abayomi; Chen, Zikang; et al., "FusionPub, a Therapeutic Landscape of Human Fusion Genes" (2025). Faculty, Staff and Student Publications. 664.
https://digitalcommons.library.tmc.edu/uthshis_docs/664