Diverse Clinical Manifestations and Challenges of Mucormycosis: Insights From Serial Cases

Authors

Marisa C Nielsen
Filipe M Cerqueira
Sri Bharathi Kavuri
Caitlin M Raymond
Aeman Muneeb
Andrzej S Kudlicki
Shafaq Tariq
Mingru Liu
Andrew L Routh
Suimin Qiu
Ping Ren

Language

English

Publication Date

11-1-2023

Journal

Open Forum Infectious Diseases

DOI

10.1093/ofid/ofad527

PMID

39139204

PMCID

PMC11320587

PubMedCentral® Posted Date

10-24-2023

PubMedCentral® Full Text Version

Post-print

Abstract

Mucormycosis is a severe and potentially life-threatening infection caused by a group of fungi classified as mucormycetes within the scientific order Mucorales. These infections are characterized by rapid and invasive fungal growth, presenting significant treatment challenges. Here we present 5 cases encountered from 2018 to 2022 at the University of Texas Medical Branch in Galveston, Texas, including a novel Apophysomyces species. These cases illustrate the diverse clinical manifestations of mucormycosis, including pulmonary, rhino-cerebral, gastrointestinal, and soft tissue involvement. Our investigation incorporates information provided by a multidisciplinary team of clinical collaborators, emphasizing the findings from radiology, histopathology, and microbiology. Given the escalating global incidence of mucormycosis, it is crucial for clinicians to become familiar with associated clinical findings, comorbidities, and risk factors to facilitate prompt recognition, appropriate diagnostic testing, and timely initiation of treatment.

Keywords

Apophysomyces, clinical mycology, fungal infections, mucormycetes, mucormycosis

Published Open-Access

yes

Recommended Citation

Nielsen, Marisa C; Cerqueira, Filipe M; Kavuri, Sri Bharathi; et al., "Diverse Clinical Manifestations and Challenges of Mucormycosis: Insights From Serial Cases" (2023). Faculty, Staff and Student Publications. 746.
https://digitalcommons.library.tmc.edu/uthshis_docs/746