Faculty, Staff and Student Publications

Language

English

Publication Date

12-1-2025

Journal

Catheterization and Cardiovascular Interventions

DOI

10.1002/ccd.70206

PMID

40995870

PMCID

PMC12679516

PubMedCentral® Posted Date

9-25-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Background: Transcatheter aortic valve replacement (TAVR) has become a popular alternative to surgical aortic valve replacement (SAVR) for patients with valvular heart disease (VHD), particularly for those with aortic anomalies.

Aims: The study aimed to compare the risks of post-TAVR complications between patients with bicuspid and tricuspid aortic valves and to identify associated risk factors.

Methods: The association between complications and valve type (bicuspid or tricuspid) was assessed. The study also explored various combinations of factors to understand their impact on complications. Separate analyses were conducted to identify specific risk factors for each complication.

Results: Out of the 1154 eligible patients, 508 had bicuspid aortic valves (BAV) and 646 had tricuspid aortic valves (TAV). The study identified 40 cases of acute kidney injury, 134 instances of new-onset permanent pacemaker implantations, 129 occurrences of paravalvular leak, and 30 device successes. The comprehensive logistic regression revealed no statistically significant association between complications and valve type (ORs: 0.52 (95% CI, 0.23-1.09) for acute kidney injury, 1.29 (95% CI, 0.87-1.92) for permanent pacemaker implantation, 1.29 (95% CI, 0.82-2.02) for paravalvular leak, and 0.54 (95% CI, 0.22-1.23) for device success). Total bilirubin (TBIL), albumin (ALB), age, and New York Heart Association (NYHA) scores, among other factors, were associated with specific post-TAVR complications.

Conclusions: The incidence of acute kidney injury, new permanent pacemaker implantations, paravalvular leaks, and device success did not differ significantly between patients with BAV and TAV following TAVR. Specific risk factors for these complications were identified, highlighting the importance of careful clinical monitoring in post-TAVR management.

Keywords

Humans, Male, Retrospective Studies, Female, Risk Factors, Transcatheter Aortic Valve Replacement, Bicuspid Aortic Valve Disease, Treatment Outcome, Aortic Valve, Aged, Heart Valve Diseases, Aged, 80 and over, Risk Assessment, Time Factors, Postoperative Complications, Aortic Valve Stenosis, Acute Kidney Injury, Pacemaker, Artificial, Heart Valve Prosthesis, Cardiac Pacing, Artificial, bicuspid aortic valves (BAV), cohort study, complications, transcatheter aortic valve replacement (TAVR), tricuspid aortic valves (TAV)

Published Open-Access

yes

Download

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.