Leveraging Informative Missing Data to Learn About Acute Respiratory Distress Syndrome and Mortality in Long-Term Hospitalized COVID-19 Patients Throughout the Years of the Pandemic

Authors

• Emily Getzen
• Amelia Lm Tan
• Gabriel Brat
• Gilbert S Omenn
• Zachary Strasser
• Qi Long
• John H Holmes
• Danielle Mowery

Language

English

Publication Date

1-1-2023

Journal

AMIA 2026 Annual Symposium

PMID

38222425

PMCID

PMC10785926

PubMedCentral® Posted Date

1-11-2024

PubMedCentral® Full Text Version

Post-print

Abstract

Electronic health records (EHRs) contain a wealth of information that can be used to further precision health. One particular data element in EHRs that is not only under-utilized but oftentimes unaccounted for is missing data. However, missingness can provide valuable information about comorbidities and best practices for monitoring patients, which could save lives and reduce burden on the healthcare system. We characterize patterns of missing data in laboratory measurements collected at the University of Pennsylvania Hospital System from long-term COVID-19 patients and focus on the changes in these patterns between 2020 and 2021. We investigate how these patterns are associated with comorbidities such as acute respiratory distress syndrome (ARDS), and 90-day mortality in ARDS patients. This work displays how knowledge and experience can change the way clinicians and hospitals manage a novel disease. It can also provide insight into best practices when it comes to patient monitoring to improve outcomes.

Keywords

Humans, COVID-19, SARS-CoV-2, Pandemics, Respiratory Distress Syndrome

Published Open-Access

yes

Recommended Citation

Getzen, Emily; Tan, Amelia Lm; Brat, Gabriel; et al., "Leveraging Informative Missing Data to Learn About Acute Respiratory Distress Syndrome and Mortality in Long-Term Hospitalized COVID-19 Patients Throughout the Years of the Pandemic" (2023). Faculty, Staff and Student Publications. 906.
https://digitalcommons.library.tmc.edu/uthshis_docs/906