Faculty, Staff and Student Publications
Language
English
Publication Date
11-1-2025
Journal
Journal of Biomedical Informatics
DOI
10.1016/j.jbi.2025.104946
PMID
41138953
PMCID
PMC12885065
PubMedCentral® Posted Date
2-10-2026
PubMedCentral® Full Text Version
Author MSS
Abstract
Objective: To advance biomedical vision language model capabilities through scaling up, fine-tuning, and instruction tuning, develop vision-language models with improved performance in handling long text, explore strategies to efficiently adopt vision language models for diverse multi-modal biomedical tasks, and examine the zero-shot learning performance.
Methods: We developed two biomedical vision language models, BiomedGPT-Large and BiomedGPT-XLarge, based on an encoder-decoder-based transformer architecture. We fine-tuned the two models on 23 benchmark datasets from 6 multi-modal biomedical tasks, including one image-only task (image classification), three language-only tasks (text understanding, text summarization, and question answering), and two vision-language tasks (visual question answering and image captioning). We compared the developed scaled models with our previous BiomedGPT-Base model and existing prestigious models reported in the literature. We instruction-tuned the two models using a large-scale multi-modal biomedical instruction-tuning dataset and assessed the zero-shot learning performance and alignment accuracy.
Results and conclusion: The experimental results show that the new models developed in this study outperform our previous BiomedGPT-Base model on 17 of 23 benchmark datasets and achieve state-of-the-art performance on 15 of 23 datasets when compared to previous models reported in the literature. The new models also demonstrated improved ability in handling long text, particularly on text summarization on the MIMIC-III dataset and text understanding on the SEER dataset, with a remarkable improvement of 4.6-11.4 %. Instruction tuning on the scaled models resulted in significant enhancements in zero-shot learning ability and alignment accuracy in following complex instructions across multiple tasks, including image classification, visual question answering, and image captioning. This study develops two vision-language models in the biomedical domain and examines technologies to improve long text content in vision language models through scaling, fine-tuning, and instruction tuning. This study demonstrates the potential of vision language models to integrate multiple data modalities to solve diverse multimodal tasks in the biomedical domain.
Keywords
Humans, Natural Language Processing, Machine Learning, Language, Medical Informatics, Visual-language model, Biomedical artificial intelligence, Model scaling, Instruction tuning, Multimodal learning
Published Open-Access
yes
Recommended Citation
Peng, Cheng; Zhang, Kai; Lyu, Mengxian; et al., "Scaling Up Biomedical Vision-Language Models: Fine-Tuning, Instruction Tuning, and Multi-modal Learning" (2025). Faculty, Staff and Student Publications. 990.
https://digitalcommons.library.tmc.edu/uthshis_docs/990