Faculty, Staff and Student Publications
Publication Date
9-1-2024
Journal
JACC: Basic to Translational Science
Abstract
A common missense variant in ICAM1 among African American individuals (rs5491; pK56M) has been associated with risk of heart failure with preserved ejection fraction (HFpEF), but the pathways that lead to HFpEF among those with this variant are not clear. In this analysis of 92 circulating proteins and their associated networks, we identified 7 circulating inflammatory proteins associated with rs5491 among >600 African American individuals. Using weighted coexpression network analysis, 3 protein networks were identified, one of which was associated with rs5491. This protein network was most highly represented by members of the tumor necrosis receptor superfamily. The rs5491 variant demonstrated an inflammatory proteomic profile in a separate cohort of African American individuals. This analysis identifies inflammatory pathways that may drive HFpEF among African American individuals with the ICAM1 pK56M (rs5491) variant.
DOI
10.1016/j.jacbts.2024.05.016
PMID
39444934
PMCID
PMC11494391
PubMedCentral® Posted Date
8-14-2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
