Faculty, Staff and Student Publications

Language

English

Publication Date

9-1-2024

Journal

JACC: Basic to Translational Science

DOI

10.1016/j.jacbts.2024.05.016

PMID

39444934

PMCID

PMC11494391

PubMedCentral® Posted Date

8-14-2024

PubMedCentral® Full Text Version

Post-print

Abstract

A common missense variant in ICAM1 among African American individuals (rs5491; pK56M) has been associated with risk of heart failure with preserved ejection fraction (HFpEF), but the pathways that lead to HFpEF among those with this variant are not clear. In this analysis of 92 circulating proteins and their associated networks, we identified 7 circulating inflammatory proteins associated with rs5491 among >600 African American individuals. Using weighted coexpression network analysis, 3 protein networks were identified, one of which was associated with rs5491. This protein network was most highly represented by members of the tumor necrosis receptor superfamily. The rs5491 variant demonstrated an inflammatory proteomic profile in a separate cohort of African American individuals. This analysis identifies inflammatory pathways that may drive HFpEF among African American individuals with the ICAM1 pK56M (rs5491) variant.

Published Open-Access

yes

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