Faculty, Staff and Student Publications

Language

English

Publication Date

4-11-2025

Journal

Nature Communications

DOI

10.1038/s41467-025-58574-z

PMID

40210677

PMCID

PMC11985957

PubMedCentral® Posted Date

4-11-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Here, we present a multi-omics study of type 2 diabetes and quantitative blood lipid and lipoprotein traits conducted to date in Hispanic/Latino populations (nmax = 63,184). We conduct a meta-analysis of 16 type 2 diabetes and 19 lipid trait GWAS, identifying 20 genome-wide significant loci for type 2 diabetes, including one novel locus and novel signals at two known loci, based on fine-mapping. We also identify sixty-one genome-wide significant loci across the lipid/lipoprotein traits, including nine novel loci, and novel signals at 19 known loci through fine-mapping. Next, we analyze genetically regulated expression, perform Mendelian randomization, and analyze association with transcriptomic and proteomic measure using multi-omics data from a Hispanic/Latino population. Using this approach, we identify genes linked to type 2 diabetes and lipid/lipoprotein traits, including TMEM205 and NEDD9 for HDL cholesterol, TREH for triglycerides, and ANXA4 for type 2 diabetes.

Keywords

Female, Humans, Male, Cholesterol, HDL, Diabetes Mellitus, Type 2, Genetic Predisposition to Disease, Genome-Wide Association Study, Hispanic or Latino, Lipids, Membrane Proteins, Mendelian Randomization Analysis, Multiomics, Polymorphism, Single Nucleotide, Proteomics, Quantitative Trait Loci, Triglycerides

Published Open-Access

yes

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