Faculty, Staff and Student Publications

Language

English

Publication Date

1-1-2025

Journal

International Journal of Public Health

DOI

10.3389/ijph.2025.1607246

PMID

40170693

PMCID

PMC11959304

PubMedCentral® Posted Date

3-18-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Objective: To characterize the clinical phenotypes of SARS-CoV-2 infection in hospitalized children as part of the EPICO multicenter cohort study.

Methods: We included hospitalized children with confirmed SARS-CoV-2 infection from Colombian and Spanish institutions to assess disease evolution and outcomes. Cluster analysis was performed to identify clinical phenotypes.

Results: A total of 2318 patients were included (55% male, 36% infants). Five phenotype clusters emerged: Cluster 1 (26.5%): infants without comorbidities, low PICU admissions and mortality; Cluster 2 (18.5%): respiratory comorbidities, high microorganism co-detection and mortality; Cluster 3 (11.5%): fever, gastrointestinal symptoms, high PICU admissions; Cluster 4 (32%): mild unspecific symptoms, low mortality; Cluster 5 (11.3%): adolescents without comorbidities, low co-detection and hospitalization rates. Findings were consistent across both countries.

Conclusion: Identifying clinical phenotypes of SARS-CoV-2 in children may improve risk stratification and guide future management strategies.

Keywords

Humans, COVID-19, Male, Female, Infant, Child, Child, Preschool, Severity of Illness Index, Hospitalization, Adolescent, Phenotype, Colombia, SARS-CoV-2, Spain, Comorbidity, Cluster Analysis, Cohort Studies, COVID-19, pediatrics, inpatients, cluster analysis, SARS-CoV-2 variants

Comments

This article has been corrected. See Int J Public Health. 2025 Apr 22;70:1608555.

Published Open-Access

yes

Additional Files
ijph-70-1608555.pdf (549 kB)
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