Faculty, Staff and Student Publications
Language
English
Publication Date
1-1-2025
Journal
The Cleft Palate-Craniofacial Journal
DOI
10.1177/10556656231198945
PMID
37671412
PMCID
PMC11363204
PubMedCentral® Posted Date
1-1-2026
PubMedCentral® Full Text Version
Author MSS
Abstract
Objective: To develop risk prediction models for preterm birth among infants with orofacial clefts.
Design: Data from the Texas Birth Defects Registry for infants with orofacial clefts born between 1999-2014 were used to develop preterm birth predictive models. Logistic regression was used to consider maternal and infant characteristics, and internal validation of the final model was performed using bootstrapping methods. The area under the curve (AUC) statistic was generated to assess model performance, and separate predictive models were built and validated for infants with cleft lip and cleft palate alone. Several secondary analyses were conducted among subgroups of interest.
Setting: State-wide, population-based Registry data.
Patients/participants: 6774 infants with orofacial clefts born in Texas between 1999-2014.
Main outcome measure(s): Preterm birth among infants with orofacial clefts.
Results: The final predictive model performed modestly, with an optimism-corrected AUC of 0.67 among all infants with orofacial clefts. The optimism-corrected models for cleft lip (with or without cleft palate) and cleft palate alone had similar predictive capability, with AUCs of 0.66 and 0.67, respectively. Secondary analyses had similar results, but the model among infants with delivery prior to 32 weeks demonstrated higher optimism-corrected predictive capability (AUC = 0.74).
Conclusions: This study provides a first step towards predicting preterm birth risk among infants with orofacial clefts. Identifying pregnancies affected by orofacial clefts at the highest risk for preterm birth may lead to new avenues for improving outcomes among these infants.
Keywords
Humans, Cleft Palate, Cleft Lip, Female, Infant, Newborn, Premature Birth, Male, Texas, Registries, Risk Assessment, Pregnancy, Adult, Risk Factors
Published Open-Access
yes
Recommended Citation
Ludorf, Katherine L; Benjamin, Renata H; Canfield, Mark A; et al., "Prediction of Preterm Birth Among Infants With Orofacial Cleft Defects" (2025). Faculty, Staff and Student Publications. 1127.
https://digitalcommons.library.tmc.edu/uthsph_docs/1127