Faculty, Staff and Student Publications
Language
English
Publication Date
7-1-2023
Journal
The Cleft Palate-Craniofacial Journal
DOI
10.1177/10556656221080932
PMID
35225696
PMCID
PMC11104489
PubMedCentral® Posted Date
7-1-2024
PubMedCentral® Full Text Version
Author MSS
Abstract
To describe the current epidemiology of nonsyndromic cleft palate alone (CP) and cleft lip with or without cleft palate (CL ± P) in Texas and examine differences in the characteristics of infants with CP and CL ± P based on the presence/absence of additional defects. We used data from the Texas Birth Defects Registry, a statewide active birth defect surveillance system, from 1815 cases with CP and 5066 with CL ± P, without a syndrome diagnosis (1999-2014 deliveries). All live births in Texas were used for comparison. Poisson regression was used to calculate crude and adjusted prevalence ratios (aPR) for each characteristic, separately for each cleft subphenotype. The prevalence of CL ± P and CP in our study was estimated as 8.3 and 3.0 per 10 000 live births, respectively. After adjusting for several characteristics, several factors were associated with CL ± P, CP, or both, including infant sex and maternal race/ethnicity, age, smoking, and diabetes. There were several differences between infants with isolated versus nonisolated clefts. For example, maternal prepregnancy diabetes was associated with an increased prevalence of CL ± P (aPR 7.91, 95% confidence interval [CI]: 5.53, 11.30) and CP (aPR 3.24, 95% CI: 1.43, 7.36), but only when additional defects were present. Findings from this study provide a contemporary description of the distribution of orofacial clefts in Texas accounting for differences between isolated and nonisolated clefts. They may contribute to increasing our understanding of the etiology of CP and CL ± P.
Keywords
Infant, Humans, Cleft Lip, Cleft Palate, Texas, Retrospective Studies, Prevalence, cleft lip, cleft palate, orofacial clefts, nonsyndromic, co-occurring defects, epidemiology
Published Open-Access
yes
Recommended Citation
Navarro Sanchez, Maria Luisa; Swartz, Michael D; Langlois, Peter H; et al., "Epidemiology of Nonsyndromic, Orofacial C/lefts in Texas: Differences by Cleft Type and Presence of Additional Defects" (2023). Faculty, Staff and Student Publications. 1130.
https://digitalcommons.library.tmc.edu/uthsph_docs/1130