Faculty, Staff and Student Publications

Language

English

Publication Date

8-1-2025

Journal

Molecular Psychiatry

DOI

10.1038/s41380-025-02954-w

PMID

40181193

PMCID

PMC12683674

PubMedCentral® Posted Date

12-9-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discovered 22 novel gene-sleep duration interaction loci for blood pressure, mapped to 23 genes. Investigating these genes' functional implications shed light on neurological, thyroidal, bone metabolism, and hematopoietic pathways that necessitate future investigation for blood pressure management that caters to sleep health lifestyle. Non-overlap between short sleep (12) and long sleep (10) interactions underscores the plausible nature of distinct influences of both sleep duration extremes in cardiovascular health. Several of our loci are specific towards a particular population background or sex, emphasizing the importance of addressing heterogeneity entangled in gene-environment interactions, when considering precision medicine design approaches for blood pressure management.

Keywords

Humans, Blood Pressure, Sleep, Genome-Wide Association Study, Male, Female, Middle Aged, Hypertension, Adult, Polymorphism, Single Nucleotide, Gene-Environment Interaction, Aged, Genetic Predisposition to Disease, Sleep Duration

Published Open-Access

yes

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