Faculty, Staff and Student Publications
Language
English
Publication Date
3-1-2023
Journal
Annals of Neurology
DOI
10.1002/ana.26569
PMID
36511390
PMCID
PMC9974745
PubMedCentral® Posted Date
3-1-2024
PubMedCentral® Full Text Version
Author MSS
Abstract
We examined associations of an AD genetic risk score (AD-GRS) and midlife cognitive and neuroimaging outcomes in 1,252 middle-aged participants (311 with brain MRI). A higher AD-GRS based on 25 previously identified loci (excluding APOE) was associated with worse Montreal Cognitive Assessment (−0.14 SD[95% CI:−0.26,−0.02]), older machine learning predicted brain age (2.35 years[95%CI:0.01,4.69]), and white matter hyperintensity volume (0.35 SD [95% CI:0.00,0.71), but not with a composite cognitive outcome, total brain, or hippocampal volume. APOE ε4 allele was not associated with any outcomes. AD risk genes beyond APOE may contribute to subclinical differences in cognition and brain health in midlife.
Keywords
Middle Aged, Humans, Child, Preschool, Alzheimer Disease, Brain, Aging, Cognition, Apolipoproteins E, Apolipoprotein E4
Published Open-Access
yes
Recommended Citation
Brenowitz, Willa D; Fornage, Myriam; Launer, Lenore J; et al., "Alzheimer's Disease Genetic Risk, Cognition, and Brain Aging in Midlife" (2023). Faculty, Staff and Student Publications. 1219.
https://digitalcommons.library.tmc.edu/uthsph_docs/1219