Faculty, Staff and Student Publications
Publication Date
1-1-2021
Journal
Journal of Ophthalmology
Abstract
PURPOSE: to determine risk factors that affect nonproliferative diabetic retinopathy (NPDR) progression and establish a predictive model to estimate the probability of and time to progression in NPDR.
RESULTS: Two hundred thirty patients were included. Initially, 65 eyes (28.3%) had no retinopathy; 73 (31.7%) mild NPDR; 60 (26.1%) moderate NPDR; and 32 (13.9%) severe NPDR. Patients were followed for a mean of 5.8 years (±2.0 years; range 2.1-9.4 years). 164 (71.3%) eyes progressed during the follow-up. Time-independent risk factors affecting progression rate were age (hazard ratio (HR) = 0.99,
CONCLUSION: HbA1c level is a significant modifiable risk factor in controlling the progression of DR. The proposed model could be used to predict the time and rate of progression based on an individual's risk factors. A prospective multicenter study should be conducted to further validate our model.
DOI
10.1155/2021/6064525
PMID
34888097
PMCID
PMC8651358
PubMedCentral® Posted Date
November 2021
PubMedCentral® Full Text Version
Post-print
Included in
Endocrinology, Diabetes, and Metabolism Commons, Internal Medicine Commons, Ophthalmology Commons, Public Health Commons