Faculty, Staff and Student Publications
Language
English
Publication Date
1-1-2026
Journal
Gastro Hep Advances
DOI
10.1016/j.gastha.2025.100767
PMID
41140766
PMCID
PMC12546776
PubMedCentral® Posted Date
8-26-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Background and aims: Risk factors for immune checkpoint inhibitor (ICI) therapy enterocolitis (IMC) have not been greatly explored. Abdominal surgery can reduce bacterial diversity, increase the presence of pathogenic bacteria, and lead to inflammatory changes. This retrospective analysis seeks to determine if a history of recent abdominal surgery in patients who receive ICI therapy affects the severity and duration of enterocolitis.
Methods: We retrospectively reviewed patients with history of abdominal surgeries, who received ICI for cancers and then developed IMC. Clinical profiles, oncology variables, and colitis-related characteristics were reported.
Results: Seven hundred sixty-five patients met the inclusion criteria. Patients median age was 64 years, were predominantly Caucasian (78.2%), and male (58.1%). Melanoma and genitourinary cancers both had 29.5% (N = 222) patients. Programmed death-1/ligand-1 agents (50.2%) or combination therapy (44.2%) were the most common treatments. Patients with a history of abdominal surgery (N = 352) had higher rates of upper GI immune-related adverse events (24 vs 16%, P = .014) compared to patients without (N = 444). Those with abdominal surgery within 3 years of IMC (N = 111) had significantly higher rates of hospitalization (72.1 vs 59.8%), recurrence of symptoms (59.6% vs 42.2%), upper GI immune-related adverse events (25.2 vs 16.4%) and worse overall survival (P = .025). Concomitant antibiotic use (N = 31) led to even higher rates of hospitalization (80.6%), recurrence of symptoms (62.1%), and upper GI symptoms (42.9%).
Conclusion: Surgery within 3 years of IMC diagnosis confers an increased IMC severity with high rates of hospitalization, recurrence, upper gastrointestinal adverse events, and decreased overall survival. Concomitant antibiotic usage serves as an effect modifier increasing the severity of the disease course.
Keywords
Immune Checkpoint Inhibitors, Immune-Related Adverse Events, Immune Checkpoint Inhibitor Colitis, Abdominal Surgery, Selective Immunosuppressive Therapy
Published Open-Access
yes
Recommended Citation
Ahuja, Rohan; Shatila, Malek; Shah, Jay; et al., "Recent Abdominal Surgery as a Risk Factor for Unfavorable Immune-Mediated Colitis Outcomes" (2026). Faculty, Staff and Student Publications. 1312.
https://digitalcommons.library.tmc.edu/uthsph_docs/1312