Susceptible Windows of Prenatal and Postnatal Fine Particulate Matter Exposures and Attention-Deficit Hyperactivity Disorder Symptoms in Early Childhood

Authors

Wei-Jen Chen
Alison M Rector-Houze
Mònica Guxens
Carmen Iñiguez
Michael D Swartz
Elaine Symanski
Jesús Ibarluzea
Antonia Valentin
Aitana Lertxundi
Llúcia González-Safont
Jordi Sunyer
Kristina W Whitworth

Language

English

Publication Date

2-20-2024

Journal

Science of the Total Environment

DOI

10.1016/j.scitotenv.2023.168806

PMID

38016567

PMCID

PMC12040439

PubMedCentral® Posted Date

4-29-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

Few prior studies have explored windows of susceptibility to fine particulate matter (PM_2.5) in both the prenatal and postnatal periods and children’s attention-deficit/hyperactivity disorder (ADHD) symptoms.

We analyzed data from 1,416 mother-child pairs from the Spanish INMA (INfancia y Medio Ambiente) Study (2003–2008). Around 5 years of age, teachers reported the number of ADHD symptoms (i.e., inattention, hyperactivity/impulsivity) using the ADHD Diagnostic and Statistical Manual of Mental Disorders. Around 7 years of age, parents completed the Conner’s Parent Rating Scales, from which we evaluated the ADHD index, cognitive problems/inattention, hyperactivity, and oppositional subscales, reported as age- and sex-standardized T-scores. Daily residential PM_2.5 exposures were estimated using a two-stage random forest model with temporal back-extrapolation and averaged over 1-week periods in the prenatal period and 4-week periods in the postnatal period. We applied distributed lag non-linear models within the Bayesian hierarchical model framework to identify susceptible windows of prenatal or postnatal exposure to PM_2.5 (per 5-μg/m³) for ADHD symptoms. Models were adjusted for relevant covariates, and cumulative effects were reported by aggregating risk ratios (RR_cum) or effect estimates (β_cum) across adjacent susceptible windows.

A similar susceptible period of exposure to PM_2.5 (1.2–2.9 and 0.9–2.7 years of age, respectively) was identified for hyperactivity/impulsivity symptoms assessed ~5 years (RR_cum=2.72, 95% credible interval [CrI]=1.98, 3.74) and increased hyperactivity subscale ~7 years (β_cum=3.70, 95%CrI=2.36, 5.03). We observed a susceptibility period to PM_2.5 on risk of hyperactivity/impulsivity symptoms ~5 years in gestational weeks 16–22 (RR_cum=1.36, 95%CrI=1.22, 1.52). No associations between PM_2.5 exposure and other ADHD symptoms were observed.

We report consistent evidence of toddlerhood as a susceptible window of PM_2.5 exposure for hyperactivity in young children. Although mid-pregnancy was identified as a susceptible period of exposure on hyperactivity symptoms in preschool-aged children, this association was not observed at the time children were school-aged.

Keywords

Pregnancy, Female, Humans, Child, Preschool, Child, Attention Deficit Disorder with Hyperactivity, Particulate Matter, Bayes Theorem, Data Collection, Air pollution, PM2.5, Susceptible windows, Attention-deficit/hyperactivity disorder, Hyperactivity symptoms

Published Open-Access

yes

Recommended Citation

Chen, Wei-Jen; Rector-Houze, Alison M; Guxens, Mònica; et al., "Susceptible Windows of Prenatal and Postnatal Fine Particulate Matter Exposures and Attention-Deficit Hyperactivity Disorder Symptoms in Early Childhood" (2024). Faculty, Staff and Student Publications. 1338.
https://digitalcommons.library.tmc.edu/uthsph_docs/1338