Student and Faculty Publications
Publication Date
5-14-2021
Journal
ACS Infectious Diseases
Abstract
Cryptosporidiosis is a leading cause of moderate-to-severe diarrhea in low- and middle-income countries, responsible for high mortality in children younger than two years of age, and it is also strongly associated with childhood malnutrition and growth stunting. There is no vaccine for cryptosporidiosis and existing therapeutic options are suboptimal to prevent morbidity and mortality in young children. Recently, novel therapeutic agents have been discovered through high-throughput phenotypic and target-based screening strategies, repurposing malaria hits, etc., and these agents have a promising preclinical in vitro and in vivo anti-
Keywords
Adult, Antiparasitic Agents, Child, Child, Preschool, Cryptosporidiosis, Cryptosporidium, Diarrhea, Humans, Malaria