Faculty, Staff and Student Publications

Language

English

Publication Date

1-1-2023

Journal

PLoS One

DOI

10.1371/journal.pone.0293874

PMID

38011138

PMCID

PMC10681164

PubMedCentral® Posted Date

11-27-2023

PubMedCentral® Full Text Version

Post-print

Abstract

Exercise clinical trials are complex, logistically burdensome, and require a well-coordinated multi-disciplinary approach. Challenges include managing, curating, and reporting on many disparate information sources, while remaining responsive to a variety of stakeholders. The Combined Exercise Trial (COMET, NCT04848038) is a one-year comparison of three exercise modalities delivered in the community. Target enrollment is 280 individuals over 4 years. To support rigorous execution of COMET, the study team has developed a suite of scripts and dashboards to assist study stakeholders in each of their various functions. The result is a highly automated study system that preserves rigor, increases communication, and reduces staff burden. This manuscript describes system considerations and the COMET approach to data management and use, with a goal of encouraging further development and adaptation by other study teams in various fields.

Keywords

Humans, Communication, Exercise

Published Open-Access

yes

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