Genome-Wide association Study of Serum Metabolites in the african american Study of Kidney Disease and Hypertension

Authors

Shengyuan Luo
Elena V Feofanova
Adrienne Tin
Sarah Tung
Eugene P Rhee
Josef Coresh
Dan E Arking
Aditya Surapaneni
Pascal Schlosser
Yong Li
Anna Köttgen
Bing Yu
Morgan E Grams

Publication Date

8-1-2021

Journal

Kidney International

Abstract

The genome-wide association study (GWAS) is a powerful means to study genetic determinants of disease traits and generate insights into disease pathophysiology. to date, few GWAS of circulating metabolite levels have been performed in African Americans with chronic kidney disease. Hypothesizing that novel genetic-metabolite associations may be identified in a unique population of African Americans with a lower glomerular filtration rate (GFR), we conducted a GWAS of 652 serum metabolites in 619 participants (mean measured glomerular filtration rate 45 mL/min/1.73m

Keywords

Black or African American, Genome-Wide Association Study, Humans, Hypertension, Polymorphism, Single Nucleotide, Renal Insufficiency, Chronic