Faculty, Staff and Student Publications
Publication Date
8-1-2021
Journal
Kidney International
Abstract
The genome-wide association study (GWAS) is a powerful means to study genetic determinants of disease traits and generate insights into disease pathophysiology. to date, few GWAS of circulating metabolite levels have been performed in African Americans with chronic kidney disease. Hypothesizing that novel genetic-metabolite associations may be identified in a unique population of African Americans with a lower glomerular filtration rate (GFR), we conducted a GWAS of 652 serum metabolites in 619 participants (mean measured glomerular filtration rate 45 mL/min/1.73m
Keywords
Black or African American, Genome-Wide Association Study, Humans, Hypertension, Polymorphism, Single Nucleotide, Renal Insufficiency, Chronic