Unraveling the Functional Role of the orphan Solute Carrier, SLC22A24 in the Transport of Steroid Conjugates Through Metabolomic and Genome-Wide association Studies

Authors

Sook Wah Yee
Adrian Stecula
Huan-Chieh Chien
Ling Zou
Elena V Feofanova
Marjolein van Borselen
Kit Wun Kathy Cheung
Noha A Yousri
Karsten Suhre
Jason M Kinchen
Eric Boerwinkle
Roshanak Irannejad
Bing Yu
Kathleen M Giacomini

Publication Date

9-1-2019

Journal

PLos Genetics

Abstract

Variation in steroid hormone levels has wide implications for health and disease. The genes encoding the proteins involved in steroid disposition represent key determinants of interindividual variation in steroid levels and ultimately, their effects. Beginning with metabolomic data from genome-wide association studies (GWAS), we observed that genetic variants in the orphan transporter, SLC22A24 were significantly associated with levels of androsterone glucuronide and etiocholanolone glucuronide (sentinel SNPs p-value

Keywords

Androsterone, Animals, Biological Transport, Genome-Wide Association Study, HEK293 Cells, Humans, Metabolomics, Models, Molecular, Organic Cation Transport Proteins, Phylogeny, Polymorphism, Single Nucleotide, Steroids, Symporters

DOI

10.1371/journal.pgen.1008208

PMID

31553721

PMCID

PMC6760779

PubMedCentral® Posted Date

September 2019

PubMedCentral® Full Text Version

Post-print