Journal Articles

Publication Date



PLos Genetics


Variation in steroid hormone levels has wide implications for health and disease. The genes encoding the proteins involved in steroid disposition represent key determinants of interindividual variation in steroid levels and ultimately, their effects. Beginning with metabolomic data from genome-wide association studies (GWAS), we observed that genetic variants in the orphan transporter, SLC22A24 were significantly associated with levels of androsterone glucuronide and etiocholanolone glucuronide (sentinel SNPs p-value


Androsterone, Animals, Biological Transport, Genome-Wide Association Study, HEK293 Cells, Humans, Metabolomics, Models, Molecular, Organic Cation Transport Proteins, Phylogeny, Polymorphism, Single Nucleotide, Steroids, Symporters



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