A Prospective Randomized Clinical Trial to Assess Antibiotic Pocket Irrigation on Tissue Expander Breast Reconstruction

Authors

Jennifer N Walker
Blake M Hanson
Tayler Hunter
Shelby R Simar
Jesus M Duran Ramirez
Chloe L P Obernuefemann
Rajiv P Parikh
Marissa M Tenenbaum
Julie A Margenthaler
Scott J Hultgren
Terence M Myckatyn

Publication Date

9-27-2023

Journal

Microbiology Spectrum

Abstract

Bacterial infection is the most common complication following staged post-mastectomy breast reconstruction initiated with a tissue expander (TE). to limit bacterial infection, antibiotic irrigation of the surgical site is commonly performed despite little high-quality data to support this practice. We performed a prospective randomized control trial to compare the impact of saline irrigation alone to a triple antibiotic irrigation regimen (1 g cefazolin, 80 mg gentamicin, and 50,000 units of bacitracin in 500 mL of saline) for breast implant surgery. The microbiome in breasts with cancer (

Keywords

breast microbiome, breast cancer, postantibiotic effect, human microbiome, bioinformatics, clinical trials, clinical methods, microbiome, microbiota

DOI

10.1128/spectrum.01430-23

PMID

37754546

PMCID

PMC10581127

PubMedCentral® Posted Date

September 2023

PubMedCentral® Full Text Version

Post-print