Proteomic Analysis Identifies Circulating Proteins Associated With Plasma Amyloid-β and Incident Dementia

Authors

Adrienne Tin
Kevin J Sullivan
Keenan A Walker
Jan Bressler
Rajesh Talluri
Bing Yu
Jeanette Simino
Valborg Gudmundsdottir
Valur Emilsson
Lori L Jennings
Lenore Launer
Hao Mei
Eric Boerwinkle
B Gwen Windham
Rebecca Gottesman
Vilmundur Gudnason
Josef Coresh
Myriam Fornage
Thomas H Mosley

Language

English

Publication Date

7-1-2023

Journal

Biological Psychiatry: Global Open Science

DOI

10.1016/j.bpsgos.2022.04.005

PMID

37519456

PMCID

PMC10382706

PubMedCentral® Posted Date

5-14-2022

PubMedCentral® Full Text Version

Post-print

Abstract

BACKGROUND: Plasma amyloid-β (Aβ) (Aβ

METHODS: We analyzed the association of these 3 plasma Aβ measures with 4638 circulating proteins among a subset of the participants of the Atherosclerosis Risk in Communities (ARIC) study (midlife:

RESULTS: At midlife, of the 296 Aβ-associated proteins, 8 were associated with incident dementia from midlife and late life in the ARIC study, and NPPB, IBSP, and THBS2 were replicated in the AGES-Reykjavik Study. At late life, of the 34 Aβ-associated proteins, none were associated with incident dementia at midlife, and kidney function explained 10%, 12%, and 0.2% of the variance of Aβ

CONCLUSIONS: This study identifies circulating proteins associated with plasma Aβ levels and incident dementia and informs peripheral factors associated with plasma Aβ levels.

Keywords

Amyloid beta, Dementia, IBSP, NPPB, Proteomics, THBS2

Published Open-Access

yes

Recommended Citation

Tin, Adrienne; Sullivan, Kevin J; Walker, Keenan A; et al., "Proteomic Analysis Identifies Circulating Proteins Associated With Plasma Amyloid-β and Incident Dementia" (2023). Faculty, Staff and Student Publications. 334.
https://digitalcommons.library.tmc.edu/uthsph_docs/334