Increased IGFBP2 Levels by Placenta-Derived Mesenchymal Stem Cells Enhance Glucose Metabolism in a TAA-Injured Rat Model via AMPK Signaling Pathway

Authors

Dae-Hyun Lee
Hyeri Park
Jun-Hyeong You
Jin Seok
Dong-Wook Kwon
Young-Ran Kim
Gi-Jin Kim

Language

English

Publication Date

11-20-2023

Journal

International Journal of Molecular Sciences

DOI

10.3390/ijms242216531

PMID

38003735

PMCID

PMC10671765

PubMedCentral® Posted Date

November 2023

PubMedCentral® Full Text Version

Post-print

Abstract

The insulin resistance caused by impaired glucose metabolism induces ovarian dysfunction due to the central importance of glucose as a source of energy. However, the research on glucose metabolism in the ovaries is still lacking. The objectives of this study were to analyze the effect of PD-MSCs on glucose metabolism through IGFBP2-AMPK signaling and to investigate the correlation between glucose metabolism and ovarian function. Thioacetamide (TAA) was used to construct a rat injury model. PD-MSCs were transplanted into the tail vein (2 × 10

Keywords

Rats, Animals, Thioacetamide, AMP-Activated Protein Kinases, Mesenchymal Stem Cells, Signal Transduction, Glucose, Mesenchymal Stem Cell Transplantation

Recommended Citation

Lee, Dae-Hyun; Park, Hyeri; You, Jun-Hyeong; et al., "Increased IGFBP2 Levels by Placenta-Derived Mesenchymal Stem Cells Enhance Glucose Metabolism in a TAA-Injured Rat Model via AMPK Signaling Pathway" (2023). Faculty, Staff and Student Publications. 385.
https://digitalcommons.library.tmc.edu/uthsph_docs/385