Unraveling the Prognostic Significance of fRGS Gene Family in Gastric Cancer and the Potential Implication of RGS4 in Regulating Tumor-infiltrating Fibroblast

Authors

Yalan Yang
Siyuan Xing
Xi Luo
Lulu Guan
Yao Lu
Yiting Wang
Feng Wang

Publication Date

1-1-2024

Journal

Frontiers in Molecular Biosciences

Abstract

Regulator of G-protein signaling (RGS) proteins are regulators of signal transduction mediated by G protein-coupled receptors (GPCRs). Current studies have shown that some molecules in the RGS gene family are related to the occurrence, development and poor prognosis of malignant tumors. However, the RGS gene family has been rarely studied in gastric cancer. In this study, we explored the mutation and expression profile of RGS gene family in gastric cancer, and evaluated the prognostic value of RGS expression. Then we established a prognostic model based on RGS gene family and performed functional analysis. Further studies showed that RGS4, as an independent prognostic predictor, may play an important role in regulating fibroblasts in the immune microenvironment. In conclusion, this study explores the value of RGS gene family in gastric cancer, which is of great significance for predicting the prognosis and guiding the treatment of gastric cancer.

Keywords

RGS4, gastric cancer, prognosis, fibroblast, immune infiltration

DOI

10.3389/fmolb.2024.1158852

PMID

38693916

PMCID

PMC11061405

PubMedCentral® Posted Date

April 2024

PubMedCentral® Full Text Version

Post-print