A Genome-Wide association Study of Obstructive Heart Defects among Participants in the National Birth Defects Prevention Study

Authors

Sara R Rashkin
Mario Cleves
Gary M Shaw
Wendy N Nembhard
Eirini Nestoridi
Mary M Jenkins
Paul A Romitti
Xiang-Yang Lou
Marilyn L Browne
Laura E Mitchell
Andrew F Olshan
Kevin Lomangino
Sudeepa Bhattacharyya
John S Witte
Charlotte A Hobbs

Publication Date

8-1-2022

Journal

American Journal of Medical Genetics

Abstract

Obstructive heart defects (OHDs) share common structural lesions in arteries and cardiac valves, accounting for ~25% of all congenital heart defects. OHDs are highly heritable, resulting from interplay among maternal exposures, genetic susceptibilities, and epigenetic phenomena. A genome-wide association study was conducted in National Birth Defects Prevention Study participants (N

Keywords

Case-Control Studies, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Heart Defects, Congenital, Humans, Infant, Polymorphism, Single Nucleotide

DOI

10.1002/ajmg.a.62759

PMID

35451555

PMCID

PMC9283270

PubMedCentral® Posted Date

August 2022

PubMedCentral® Full Text Version

Post-print