Exploring the Hazards of Scaling Up Clinical Data analyses: a Drug Side Effect Discovery Case Report.

Authors

Franck Diaz-Garelli
Todd R Johnson
Mohammad H Rahbar
Elmer V Bernstam

Publication Date

1-1-2021

Journal

AMIA Summits on Translational Science Proceedings

Abstract

We assessed the scalability of pharmacological signal detection use case from a single-site CDW to a large aggregated clinical data warehouse (single-site database with 754,214 distinct patient IDs vs. multisite database with 49.8M). We aimed to explore whether a larger clinical dataset would provide clearer signals for secondary analyses such as detecting the known relationship between prednisone and weight. We found significant weight gain rate using the single-site data but not from using aggregated data (0.0104 kg/day, p

Keywords

Data Warehousing, Databases, Factual, Drug-Related Side Effects and Adverse Reactions, Humans