Faculty, Staff and Student Publications
Exploring the Hazards of Scaling Up Clinical Data Analyses: A Drug Side Effect Discovery Case Report
Publication Date
1-1-2021
Journal
AMIA Summits on Translational Science Proceedings
Abstract
We assessed the scalability of pharmacological signal detection use case from a single-site CDW to a large aggregated clinical data warehouse (single-site database with 754,214 distinct patient IDs vs. multisite database with 49.8M). We aimed to explore whether a larger clinical dataset would provide clearer signals for secondary analyses such as detecting the known relationship between prednisone and weight. We found significant weight gain rate using the single-site data but not from using aggregated data (0.0104 kg/day, p
Keywords
Data Warehousing, Databases, Factual, Drug-Related Side Effects and Adverse Reactions, Humans
PMID
34457132
PMCID
PMC8378643
PubMedCentral® Posted Date
May 2021
PubMedCentral® Full Text Version
Post-print