Additive and Interactive Associations of Environmental and Sociodemographic Factors with the Genotypes of Three Glutathione S-Transferase Genes in Relation to the Blood Arsenic Concentrations of Children in Jamaica

Authors

Mohammad H Rahbar
Maureen Samms-Vaughan
Yuansong Zhao
Sepideh Saroukhani
Sheikh F Zaman
Jan Bressler
Manouchehr Hessabi
Megan L Grove
Sydonnie Shakspeare-Pellington
Katherine A Loveland

Publication Date

1-1-2022

Journal

International Journal of Environmental Research and Public Health

Abstract

Arsenic (As) is a metalloid that has been classified as a xenobiotic with toxic effects on human beings, especially on children. Since the soil in Jamaica contains As, dietary intake is considered the main source of As exposure in Jamaicans. In addition, glutathione S-transferase (GST) genes, including

Keywords

Arsenic, Case-Control Studies, Child, Genetic Predisposition to Disease, Genotype, Glutathione S-Transferase pi, Glutathione Transferase, Humans, Jamaica, Polymorphism, Genetic, Risk Factors, Sociodemographic Factors

DOI

10.3390/ijerph19010466

PMID

35010728

PMCID

PMC8745014

PubMedCentral® Posted Date

January 2022

PubMedCentral® Full Text Version

Post-print