Curated and Harmonized Gut Microbiome 16S rRNA Amplicon Data From Dietary Fiber Intervention Studies in Humans

Authors

Cynthia I Rodriguez
Ali Keshavarzian
Bruce R Hamaker
Feitong Liu
Genelle R Lunken
Heather Rasmussen
Hongwei Zhou
Julien Tap
Kelly S Swanson
Maria Ukhanova
Marion Leclerc
Martin Gotteland
Paola Navarrete
Petia Kovatcheva-Datchary
Wendy J Dahl
Jennifer B H Martiny

Publication Date

6-2-2023

Journal

Scientific Data

Abstract

Next generation amplicon sequencing has created a plethora of data from human microbiomes. The accessibility to this scientific data and its corresponding metadata is important for its reuse, to allow for new discoveries, verification of published results, and serving as path for reproducibility. Dietary fiber consumption has been associated with a variety of health benefits that are thought to be mediated by gut microbiota. To enable direct comparisons of the response of the gut microbiome to fiber, we obtained 16S rRNA sequencing data and its corresponding metadata from 11 fiber intervention studies for a total of 2,368 samples. We provide curated and pre-processed genetic data and common metadata for comparison across the different studies.

Keywords

Humans, Dietary Fiber, Gastrointestinal Microbiome, Microbiota, Reproducibility of Results, RNA, Ribosomal, 16S