Mendelian Randomization Supports Bidirectional Causality Between Telomere Length and Clonal Hematopoiesis of Indeterminate Potential

Authors

• Tetsushi Nakao
• Alexander G Bick
• Margaret A Taub
• Seyedeh M Zekavat
• Md M Uddin
• Abhishek Niroula
• Cara L Carty
• John Lane
• Michael C Honigberg
• Joshua S Weinstock
• Akhil Pampana
• Christopher J Gibson
• Gabriel K Griffin
• Shoa L Clarke
• Romit Bhattacharya
• Themistocles L Assimes
• Leslie S Emery
• Adrienne M Stilp
• Quenna Wong
• Jai Broome
• Cecelia A Laurie
• Alyna T Khan
• Albert V Smith
• Thomas W Blackwell
• Veryan Codd
• Christopher P Nelson
• Zachary T Yoneda
• Juan M Peralta
• Donald W Bowden
• Marguerite R Irvin
• Meher Boorgula
• Wei Zhao
• Lisa R Yanek
• Kerri L Wiggins
• James E Hixson
• C Charles Gu
• Gina M Peloso
• Dan M Roden
• Muagututi'a S Reupena
• Chii-Min Hwu
• Dawn L DeMeo
• Kari E North
• Shannon Kelly
• Solomon K Musani
• Joshua C Bis
• Donald M Lloyd-Jones
• Jill M Johnsen
• Michael Preuss
• Russell P Tracy
• Patricia A Peyser
• Dandi Qiao
• Pinkal Desai
• Joanne E Curran
• Barry I Freedman
• Hemant K Tiwari
• Sameer Chavan
• Jennifer A Smith
• Nicholas L Smith
• Tanika N Kelly
• Bertha Hidalgo
• L Adrienne Cupples
• Daniel E Weeks
• Nicola L Hawley
• Ryan L Minster
• Samoan Obesity, Lifestyle and Genetic Adaptations Study (OLaGA) Group
• Ranjan Deka
• Take T Naseri
• Lisa de las Fuentes
• Laura M Raffield
• Alanna C Morrison
• Paul S Vries
• Christie M Ballantyne
• Eimear E Kenny
• Stephen S Rich
• Eric A Whitsel
• Michael H Cho
• M Benjamin Shoemaker
• Betty S Pace
• John Blangero
• Nicholette D Palmer
• Braxton D Mitchell
• Alan R Shuldiner
• Kathleen C Barnes
• Susan Redline
• Sharon L R Kardia
• Gonçalo R Abecasis
• Lewis C Becker
• Susan R Heckbert
• Jiang He
• Wendy Post
• Donna K Arnett
• Ramachandran S Vasan
• Dawood Darbar
• Scott T Weiss
• Stephen T McGarvey
• Mariza de Andrade
• Yii-Der Ida Chen
• Robert C Kaplan
• Deborah A Meyers
• Brian S Custer
• Adolfo Correa
• Bruce M Psaty
• Myriam Fornage
• JoAnn E Manson
• Eric Boerwinkle
• Barbara A Konkle
• Ruth J F Loos
• Jerome I Rotter
• Edwin K Silverman
• Charles Kooperberg
• John Danesh
• Nilesh J Samani
• Siddhartha Jaiswal
• Peter Libby
• Patrick T Ellinor
• Nathan Pankratz
• Benjamin L Ebert
• Alexander P Reiner
• Rasika A Mathias
• Ron Do
• NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
• Pradeep Natarajan

Language

English

Publication Date

4-8-2022

Journal

Science Advances

DOI

10.1126/sciadv.abl6579

PMID

35385311

PMCID

PMC8986098

PubMedCentral® Posted Date

4-6-2022

PubMedCentral® Full Text Version

Post-print

Abstract

Human genetic studies support an inverse causal relationship between leukocyte telomere length (LTL) and coronary artery disease (CAD), but directionally mixed effects for LTL and diverse malignancies. Clonal hematopoiesis of indeterminate potential (CHIP), characterized by expansion of hematopoietic cells bearing leukemogenic mutations, predisposes both hematologic malignancy and CAD.

Published Open-Access

yes

Recommended Citation

Nakao, Tetsushi; Bick, Alexander G; Taub, Margaret A; et al., "Mendelian Randomization Supports Bidirectional Causality Between Telomere Length and Clonal Hematopoiesis of Indeterminate Potential" (2022). Faculty, Staff and Student Publications. 703.
https://digitalcommons.library.tmc.edu/uthsph_docs/703