Faculty, Staff and Student Publications
Publication Date
6-15-2024
Journal
Heliyon
Abstract
Introduction: Young sexual minority men (SMM) bear the greatest burden of anal human papillomavirus (HPV) infections. We assessed anal HPV genotype discordance between the Linear Array (LA) and SPF10 PCR-DEIA-LiPA25 (LiPA25).
Methods: Discordance was assessed between LA and LiPA25 using self-collected anal swabs from 120 SMM aged 18-29 who were recruited in 2014-2016. Multiple-type infection was explored as a potential confounder of testing agreement, along with clinical and behavioral factors such as HIV status, syphilis status, incarceration history, health insurance coverage, having 3 or more sex partners in the past 6 months, and co-infection with HPV-16.
Results: Significant discordance was found for HPV-6, -11, -16, -31, -42, -54, and -59. Exploratory analyses suggest higher prevalence of genotype discordance in those living with HIV, those with 3 or more sex partners, and those who were positive for 4 or more HPV types.
Conclusions: Our results highlight the importance of HPV detection methods which may inform different interpretations of research assessing anal HPV natural history among SMM at highest risk for HPV.
Keywords
Human papillomavirus, Discordance, anal cancer, Sexual minority men, Screening test
DOI
10.1016/j.heliyon.2024.e32336
PMID
38933939
PMCID
PMC11200335
PubMedCentral® Posted Date
6-3-2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
