Selection for Robust Metabolism in Domesticated Yeasts Is Driven by Adaptation to Hsp90 Stress

Authors

Natalia Condic
Hatim Amiji
Dipak Patel
William Charles Shropshire
Nejla Ozirmak Lermi
Youssef Sabha
Beryl John
Blake Hanson
Georgios Ioannis Karras

Publication Date

7-26-2024

Journal

Science

Abstract

Protein folding both promotes and constrains adaptive evolution. We uncover this surprising duality in the role of the protein-folding chaperone heat shock protein 90 (Hsp90) in maintaining the integrity of yeast metabolism amid proteotoxic stressors within industrial domestication niches. Ethanol disrupts critical Hsp90-dependent metabolic pathways and exerts strong selective pressure for redundant duplications of key genes within these pathways, yielding the classical genomic signatures of beer and bread domestication. This work demonstrates a mechanism of adaptive canalization in an ecology of major economic importance and highlights Hsp90-dependent variation as an important source of phantom heritability in complex traits.

Keywords

Adaptation, Physiological, Beer, Bread, Ethanol, Gene Duplication, HSP90 Heat-Shock Proteins, Metabolic Networks and Pathways, Protein Folding, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Selection, Genetic, Stress, Physiological, Fermentation

DOI

10.1126/science.adi3048

PMID

39052788

PMCID

PMC11410103

PubMedCentral® Posted Date

9-18-2024

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes