Multisite Detection of Tn1549-Mediated vanB Vancomycin Resistance in Multidrug-Resistant Enterococcus faecalis ST6 in Texas and Florida

Authors

Shelby R Simar
Truc T Tran
Kirsten B Rydell
Diana Panesso
German A Contreras
Jose M Munita
Renzo O Cifuentes
Lilian M Abbo
Pranoti Sahasrabhojane
An Q Dinh
Dierdre B Axell-House
Tor Savidge
Samuel A Shelburne
Blake M Hanson
Cesar A Arias

Publication Date

1-24-2023

Journal

Antimicrobial Agents and Chemotherapy

Abstract

In the United States, vanB-mediated resistance in enterococci is rare. We characterized three sequence type (ST) 6, vancomycin-resistant Enterococcus faecalis isolates causing bacteremia in unique patients in spatiotemporally distinct settings. Isolates were recovered between 2018 and 2020 in two cities in the United States (Houston, TX; Miami, FL). The isolates harbored the vanB operon on a chromosomally located Tn1549 transposon, and epidemiological data suggested multiple introductions of the vanB gene cluster into ST6 E. faecalis.

Keywords

Humans, Enterococcus faecalis, Vancomycin Resistance, Enterococcus faecium, Florida, Texas, Vancomycin-Resistant Enterococci, Gram-Positive Bacterial Infections, Bacterial Proteins, Anti-Bacterial Agents, Enterococcus, VRE, antimicrobial resistance

DOI

10.1128/aac.01284-22

PMID

36541772

PMCID

PMC9872605

PubMedCentral® Posted Date

12-21-2022

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes