Faculty, Staff and Student Publications
Publication Date
1-1-2025
Journal
Journal of Hepatocellular Carcinoma
Abstract
INTRODUCTION: Hepatocellular carcinoma (HCC) disproportionately affects Hispanic persons with higher age-specific incidence and increased mortality rates compared to non-Hispanic Whites. These high rates of incidence and mortality may be explained by the variation in risk factors. Given the high prevalence of type 2 diabetes mellitus (DM) among the Hispanic population, we aimed to assess the risk and prognosis of HCC in Mexican Americans with type 2 DM with consideration of treatment for DM.
METHODS: A case-control study of 241 Mexican American HCC patients and 500 healthy controls in Texas was conducted. Multivariable logistic regression analysis was performed to determine the association between type 2 DM and HCC risk while adjusting for other risk factors. Also, a restricted analysis of patients with type 2 DM was conducted to determine the effects of age at onset and duration of DM on HCC risk. Interactions among DM, heavy alcohol consumption, and viral hepatitis infection were examined. Overall survival was examined, and multivariable Cox proportional hazards regression analysis was performed for HCC patients with type 2 DM.
RESULTS: The adjusted odds ratio (AOR) for DM was 2.74 (P < 0.01). Compared with patients who had DM for 2-10 years, those who had it for at least 20 years had an AOR of 4.60 (
CONCLUSION: Our results demonstrate that type 2 DM was independently associated with increased risk of HCC among Mexican Americans. Metformin use was associated with improved survival among HCC patients with type 2 DM. Type 2 DM significantly increased the risk of HCC alone and in conjunction with other parameters of metabolic syndrome in the Mexican American population after adjusting for other risk factors.
Keywords
diabetes mellitus, Mexican Americans, hepatocellular carcinoma, metformin, interactions
DOI
10.2147/JHC.S477141
PMID
39867264
PMCID
PMC11762437
PubMedCentral® Posted Date
1-21-2025
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Included in
Endocrine System Diseases Commons, Endocrinology, Diabetes, and Metabolism Commons, Neoplasms Commons, Oncology Commons, Public Health Commons, Race and Ethnicity Commons
