Faculty, Staff and Student Publications
Publication Date
1-1-2022
Journal
Frontiers in Public Health
Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) delta variant has been hypothesized to decrease the efficacy of COVID-19 vaccines. Factors associated with infections with SARS-CoV-2 after vaccination are unknown. In this observational cohort study, we examined two groups in Harris County, Texas: (1) individuals with positive Nucleic Acid Amplification test between 12/14/2020 and 9/30/2021 and (2) the subset of individuals fully vaccinated in the same time period. Infected individuals were classified as a breakthrough if their infection occurred 14 days after their vaccination had been completed. Among fully vaccinated individuals, demographic and vaccine factors associated with breakthrough infections were assessed. Of 146,731 positive SARS-CoV-2 tests, 7.5% were breakthrough infections. Correlates of breakthrough infection included young adult age, female, White race, and receiving the Janssen vaccine, after adjustments including the amount of community spread at the time of infection. Vaccines remained effective in decreasing the probability of testing positive for SARS-CoV-2. The data indicate that increased vaccine booster uptake would help decrease new infections.
Keywords
Female, Humans, SARS-CoV-2, Viral Vaccines, COVID-19, COVID-19 vaccine, breakthrough infection, delta variant strain, COVID-19 vaccine efficacy
DOI
10.3389/fpubh.2022.856532
PMID
35619825
PMCID
PMC9127615
PubMedCentral® Posted Date
5-10-2022
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Included in
COVID-19 Commons, Epidemiology Commons, Influenza Humans Commons, Influenza Virus Vaccines Commons
