Faculty, Staff and Student Publications
Language
English
Publication Date
12-4-2021
Journal
Translational Psychiatry
DOI
10.1038/s41398-021-01736-6
PMID
34864818
PMCID
PMC8643353
PubMedCentral® Posted Date
December 2021
PubMedCentral® Full Text Version
Post-print
Abstract
Measures of information processing speed vary between individuals and decline with age. Studies of aging twins suggest heritability may be as high as 67%. The Illumina HumanExome Bead Chip genotyping array was used to examine the association of rare coding variants with performance on the Digit-Symbol Substitution Test (DSST) in community-dwelling adults participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. DSST scores were available for 30,576 individuals of European ancestry from nine cohorts and for 5758 individuals of African ancestry from four cohorts who were older than 45 years and free of dementia and clinical stroke. Linear regression models adjusted for age and gender were used for analysis of single genetic variants, and the T5, T1, and T01 burden tests that aggregate the number of rare alleles by gene were also applied. Secondary analyses included further adjustment for education. Meta-analyses to combine cohort-specific results were carried out separately for each ancestry group. Variants in RNF19A reached the threshold for statistical significance (p = 2.01 × 10
Keywords
Adult, Aging, Cognition, Genome-Wide Association Study, Geroscience, Humans, Polymorphism, Single Nucleotide, Ubiquitin-Protein Ligases
Recommended Citation
Bressler, Jan; Davies, Gail; Smith, Albert V; et al., "Association of Low-Frequency and Rare Coding Variants With information Processing Speed" (2021). Faculty, Staff and Student Publications. 90.
https://digitalcommons.library.tmc.edu/uthsph_docs/90