Faculty, Staff and Student Publications

Language

English

Publication Date

4-11-2025

Journal

Nature Communications

DOI

10.1038/s41467-025-58420-2

PMID

40216759

PMCID

PMC11992084

PubMedCentral® Posted Date

4-11-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Obesity is a major public health crisis associated with high mortality rates. Previous genome-wide association studies (GWAS) investigating body mass index (BMI) have largely relied on imputed data from European individuals. This study leveraged whole-genome sequencing (WGS) data from 88,873 participants from the Trans-Omics for Precision Medicine (TOPMed) Program, of which 51% were of non-European population groups. We discovered 18 BMI-associated signals (P <  5 × 10

Keywords

Adult, Female, Humans, Male, Middle Aged, Alleles, Body Mass Index, Genetic Predisposition to Disease, Genome-Wide Association Study, Obesity, Polymorphism, Single Nucleotide, Whole Genome Sequencing, African People, Population Groups

Published Open-Access

yes

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