Faculty, Staff and Student Publications
Language
English
Publication Date
4-11-2025
Journal
Nature Communications
DOI
10.1038/s41467-025-58420-2
PMID
40216759
PMCID
PMC11992084
PubMedCentral® Posted Date
4-11-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Obesity is a major public health crisis associated with high mortality rates. Previous genome-wide association studies (GWAS) investigating body mass index (BMI) have largely relied on imputed data from European individuals. This study leveraged whole-genome sequencing (WGS) data from 88,873 participants from the Trans-Omics for Precision Medicine (TOPMed) Program, of which 51% were of non-European population groups. We discovered 18 BMI-associated signals (P < 5 × 10
Keywords
Adult, Female, Humans, Male, Middle Aged, Alleles, Body Mass Index, Genetic Predisposition to Disease, Genome-Wide Association Study, Obesity, Polymorphism, Single Nucleotide, Whole Genome Sequencing, African People, Population Groups
Published Open-Access
yes
Recommended Citation
Zhang, Xinruo; Brody, Jennifer A; Graff, Mariaelisa; et al., "Whole Genome Sequencing Analysis of Body Mass Index Identifies Novel African Ancestry-Specific Risk Allele" (2025). Faculty, Staff and Student Publications. 984.
https://digitalcommons.library.tmc.edu/uthsph_docs/984
Commentary