Impact of Atrial Fibrillation on Outcomes after Left Ventricular Assist Device Implantation: Systematic Review and Meta-Analysis

Authors

Chandan Buttar, Ochsner Clinic FoundationFollow
Sofia Lakhdar, Icahn School of Medicine Queens HospitalFollow
Mahmood Nassar, Icahn School of Medicine at Mount Sinai / NYC Health+Hospitals Queens, NY, USAFollow
Nso Nso, Icahn School of Medicine at Mount Sinai / NYC Health+Hospitals Queens, NY, USAFollow
Giovina Collura, Division of Cardiology, Icahn School of Medicine at Mount Sinai/NYC H+H/Queens, NYFollow
Most Sirajum Munira, Division of Cardiology, Icahn School of Medicine at Mount Sinai/NYC H+H/Queens, NYFollow

Document Type

Review

Abstract

Background: Atrial fibrillation (AF) is a common finding in patients with heart failure and is well-known for its deleterious effects on cardiac function and hemodynamics; however, there are gaps in knowledge regarding the impact of AF on patients with left ventricular assist devices (LVADs).

Methods: In this study, we searched PubMed/Medline, Embase, and Cochrane Library databases through September 2021 to find articles that assessed the outcomes of AF in patients with LVADs.

Results: A total of 12 studies that underwent systematic review evaluated the outcomes of 7853 adult patients. The meta-analysis analyzed findings from a total of 1003 patients. Pooled findings indicated a 25% higher risk of mortality in patients with AF as compared to those in sinus rhythm (P = .02). No statistically significant differences in mortality were noted between patients with paroxysmal AF or persistent AF (P = .13). No statistically significant differences were noted between the groups in terms of bleeding (P = .70). There was an increased risk of thromboembolism in patients with sinus rhythm compared to those with AF (P < .001).

Conclusion: The presence of AF was not found to be associated with an increased risk of bleeding or thromboembolism but may be associated with increased mortality.

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

Recommended Citation

Buttar, Chandan; Lakhdar, Sofia; Nassar, Mahmood; Nso, Nso; Collura, Giovina; and Munira, Most Sirajum (2022) "Impact of Atrial Fibrillation on Outcomes after Left Ventricular Assist Device Implantation: Systematic Review and Meta-Analysis," The VAD Journal: Vol. 8(1) :e2022816 DOI: https://doi.org/10.11589/vad/e2022816

Available at: https://digitalcommons.library.tmc.edu/vad/vol8/iss1/6

First Page

e2022816