Targeting the Glutamine-Arginine-Proline Metabolism Axis in Cancer

Authors

Di Wang
Jiang-Jie Duan
Yu-Feng Guo
Jun-Jie Chen
Tian-Qing Chen
Jun Wang
Shi-Cang Yu

Publication Date

12-1-2024

Journal

Journal of Enzyme Inhibition and Medicinal Chemistry

Abstract

Metabolic abnormalities are an important feature of tumours. The glutamine-arginine-proline axis is an important node of cancer metabolism and plays a major role in amino acid metabolism. This axis also acts as a scaffold for the synthesis of other nonessential amino acids and essential metabolites. In this paper, we briefly review (1) the glutamine addiction exhibited by tumour cells with accelerated glutamine transport and metabolism; (2) the methods regulating extracellular glutamine entry, intracellular glutamine synthesis and the fate of intracellular glutamine; (3) the glutamine, proline and arginine metabolic pathways and their interaction; and (4) the research progress in tumour therapy targeting the glutamine-arginine-proline metabolic system, with a focus on summarising the therapeutic research progress of strategies targeting of one of the key enzymes of this metabolic system, P5CS (ALDH18A1). This review provides a new basis for treatments targeting the metabolic characteristics of tumours.

Keywords

Humans, Glutamine, Neoplasms, Proline, Arginine, Antineoplastic Agents, Molecular Structure, Animals, Glutamine, proline, ALDH18A1, cancer, metabolism

Comments

PMID: 39051546