From Primary Myelofibrosis to Chronic Myeloid Leukemia, BCR::ABL1+ B-lymphoblastic Leukemia, and Back to Primary Myelofibrosis: An Illustration of Dynamic Clonal Evolution

Authors

Devin Wang
Wataru Kamata
Fengxi Ye
M James You

Publication Date

2-1-2024

Journal

eJHaem

Abstract

The simultaneous detection of BCR::ABL1 and JAK2 V617F was rarely reported and their clonal relationship and dynamic clonal shift were not characterized. Here, we described a unique case with the initial presentation as JAK2 V617F+ primary myelofibrosis, followed by the emergence of BCR::ABL1+ chronic myeloid leukemia. The patient then developed BCR::ABL1+ B-lymphoblastic leukemia. Treatment for B-lymphoblastic leukemia prompted a regression to the state of primary myelofibrosis. In light of these observations, we proposed a clonal evolution model for this case.

Keywords

BCR::ABL1 + B‐ALL, clonal evolution, CML, JAK2 V617F, PMF

Comments

Associated Data

PMID

38406521

PMCID

PMC10887360

Published Open-Access

yes