Language
English
Publication Date
1-1-2024
Journal
The Journal of Cardiovascular Aging
DOI
10.20517/jca.2023.38
PMID
38455510
PMCID
PMC10919906
PubMedCentral® Posted Date
3-7-2024
PubMedCentral® Full Text Version
Author MSS
Abstract
Obesity is associated with chronic inflammation in adipose tissue (AT), mainly evidenced by infiltration and phenotypic changes of various types of immune cells. Macrophages are the major innate immune cells and represent the predominant immune cell population within AT. Lymphocytes, including T cells and B cells, are adaptive immune cells and constitute another important immune cell population in AT. In obesity, CD8+ effector memory T cells, CD4+ Th1 cells, and B2 cells are increased in AT and promote AT inflammation, while regulatory T cells and Th2 cells, which usually function as immune regulatory or type 2 inflammatory cells, are reduced in AT. Immune cells may regulate the metabolism of adipocytes and other cells through various mechanisms, contributing to the development of metabolic diseases, including insulin resistance and type 2 diabetes. Efforts targeting immune cells and inflammation to prevent and treat obesity-linked metabolic disease have been explored, but have not yielded significant success in clinical studies. This review provides a concise overview of the changes in lymphocyte populations within AT and their potential role in AT inflammation and the regulation of metabolic functions in the context of obesity.
Keywords
Obesity, adipose tissue, insulin resistance, T cells, B cells
Published Open-Access
yes
Recommended Citation
, "Adipose Tissue Lymphocytes and Obesity" (2024). Faculty, Staff and Students Publications. 1050.
https://digitalcommons.library.tmc.edu/baylor_docs/1050
Graphical Abstract