Metaproteomic Analysis of Human Gut Microbiome in Digestive and Metabolic Diseases

Authors

Sheng Pan
Ru Chen

Publication Date

1-1-2020

Journal

Advances in Clinical Chemistry

DOI

10.1016/bs.acc.2019.12.002

PMID

32448430

PMCID

PMC9014827

PubMedCentral® Posted Date

4-18-2022

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes

Keywords

Digestive System Diseases, Gastrointestinal Microbiome, Humans, Metabolic Diseases, Proteins, Proteomics

Abstract

Metaproteomics, as a subfield of proteomics, has quickly emerged as a pivotal tool for global characterization of a microbiome system at a functional level. It has been increasingly applied in studying human digestive and metabolic diseases, and provides information-rich data to identify the dysbiosis of human gut microbiome related to healthy or disease states to elucidate the molecular events underlying host-microbiota interplays. While significant technical challenges still exist, this emerging technology has been demonstrated to provide essential information in interrogating functional changes in the human gut microbiome, complementary to metagenomics and metatranscriptomics. This chapter overviews the overall metaproteomic work flow and its recent applications in studying human gut microbiome relevant to digestive and metabolic diseases.

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