Language
English
Publication Date
8-9-2023
Journal
Biology
DOI
10.3390/biology12081105
PMID
37626991
PMCID
PMC10452260
PubMedCentral® Posted Date
8-9-2023
PubMedCentral® Full Text Version
Post-Print
Abstract
Bile acids serve a vital function in lipid digestion and absorption; however, their accumulation can precipitate liver damage. In our study, we probed the effects of dimethyl sulfoxide (DMSO) on bile acid synthesis and the ensuing liver damage in mice induced by bile acids. Our findings indicate that DMSO efficaciously curbs bile acid synthesis by inhibiting key enzymes involved in the biosynthetic pathway, both in cultured primary hepatocytes and in vivo. Contrarily, we observed that DMSO treatment did not confer protection against bile-acid-induced liver damage in two distinct mouse models: one induced by a 0.1% DDC diet, leading to bile duct obstruction, and another induced by a CDA-HFD, resulting in non-alcoholic steatohepatitis (NASH). Histopathological and biochemical analyses unveiled a comparable extent of liver injury and fibrosis levels in DMSO-treated mice, characterized by similar levels of increase in
Keywords
dimethyl sulfoxide (DMSO), bile acid, liver damage, nonalcoholic steatohepatitis (NASH)
Published Open-Access
yes
Recommended Citation
Chen, Xi; Li, Huiqiao; Liu, Yu'e; et al., "Dimethyl Sulfoxide Inhibits Bile Acid Synthesis in Healthy Mice but Does Not Protect Mice from Bile-Acid-Induced Liver Damage" (2023). Faculty and Staff Publications. 1367.
https://digitalcommons.library.tmc.edu/baylor_docs/1367