LOX Upregulates FAK Phosphorylation To Promote Metastasis in Osteosarcoma

Authors

Xiang Chen
Margaret Clement
M John Hicks
Poonam Sarkar
M Waleed Gaber
Tsz-Kwong Man

Publication Date

1-1-2023

Journal

Genes & Diseases

DOI

10.1016/j.gendis.2021.12.016

PMID

37013056

PMCID

PMC10066266

PubMedCentral® Posted Date

1-29-2022

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

Focal adhesion kinase, Lysyl oxidase, Metastasis, Osteosarcoma

Abstract

Osteosarcoma is a malignant bone tumor that commonly occurs in the pediatric population. Despite the use of chemotherapy and surgery, metastasis remains to be the leading cause of death in patients with osteosarcoma. We have previously reported that cytoplasmic mislocalization of p27 is associated with a poor outcome in osteosarcoma. In this study, we further show that lysyl oxidase (LOX) expression was associated with p27 mislocalization. LOX is an enigmatic molecule that acts as a tumor suppressor or a metastatic promoter; however, its role in osteosarcoma is still unclear. Hence, we performed both