Publication Date
1-1-2022
Journal
Clinical Gastroenterology and Hepatology
DOI
10.1016/j.cgh.2020.08.045
PMID
32835845
PMCID
PMC8210475
PubMedCentral® Posted Date
1-1-2023
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Keywords
Anxiety, Anxiety Disorders, Cross-Sectional Studies, Depression, Humans, Liver Cirrhosis, Male, Prevalence, Surveys and Questionnaires, United States
Abstract
BACKGROUND & AIMS: Depression and anxiety can have negative effects on patients and are important to treat. There have been few studies of their prevalence among patients with cirrhosis. We aimed to characterize the prevalence and risk factors for depression and anxiety in a large multi-center cohort of patients with cirrhosis.
METHODS: We conducted a telephone-based survey of patients with cirrhosis at 3 health systems in the United States (a tertiary-care referral center, a safety net system, and a Veterans hospital) from April through December 2018. Of 2871 patients approached, 1021 (35.6%) completed the survey. Depression and anxiety were assessed using the PHQ-9 (range 0-25) and STAI (range 20-80) instruments, with clinically significant values defined as PHQ-9 ≥15 and STAI ≥40. We performed multivariate logistic regression analysis to identify factors associated with significant depression and anxiety.
RESULTS: The median PHQ-9 score was 7 (25
CONCLUSIONS: Nearly 1 in 6 patients with cirrhosis have moderately severe to severe depression and nearly half have moderate-severe anxiety. Patients with cirrhosis should be evaluated for both of these disorders.
Comments
Associated Data