Molecular Mechanisms of Biofilm Formation in Helicobacter pylori

Authors

Kartika Afrida Fauzia
Wiwin Is Effendi
Ricky Indra Alfaray
Hoda M Malaty
Yoshio Yamaoka
Muhammad Mifthussurur

Publication Date

10-16-2024

Journal

Antibiotics

DOI

10.3390/antibiotics13100976

PMID

39452242

PMCID

PMC11504965

PubMedCentral® Posted Date

10-16-2024

PubMedCentral® Full Text Version

Post-Print

Published Open-Access

yes

Keywords

biofilm formation, H. pylori, infection, treatment, human and health

Abstract

BACKGROUND: Biofilm formation in

METHODS: We conducted a literature review analysis of the published articles on the

RESULTS: The results showed that biofilm formation starts as adhesion and progresses through micro-colonies, maturation, and dispersion in a planktonic form. Moreover, specific genes modulate each phase of biofilm formation. Few studies have shown that mechanisms, such as quorum sensing and diffusible signal factors, enhance coordination among bacteria when switching from biofilm to planktonic states. Different protein expressions were also observed between planktonic and biofilm strains, and the biofilm architecture was supported by exopolysaccharides, extracellular DNA, and outer membrane vesicles.

CONCLUSIONS: This infrastructure is responsible for the increased survival of bacteria, especially in harsh environments or in the presence of antibiotics. Therefore, understanding the biofilm formation for

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