Publication Date
9-14-2021
Journal
Journal of the American College of Cardiology
DOI
10.1016/j.jacc.2021.07.014
PMID
34503685
PMCID
PMC8525886
PubMedCentral® Posted Date
9-14-2022
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Keywords
Aging, Animals, Exercise Tolerance, Heart Failure, Diastolic, Humans
Abstract
Exercise intolerance (EI) is the primary manifestation of chronic heart failure with preserved ejection fraction (HFpEF), the most common form of heart failure among older individuals. The recent recognition that HFpEF is likely a systemic, multiorgan disorder that shares characteristics with other common, difficult-to-treat, aging-related disorders suggests that novel insights may be gained from combining knowledge and concepts from aging and cardiovascular disease disciplines. This state-of-the-art review is based on the outcomes of a National Institute of Aging-sponsored working group meeting on aging and EI in HFpEF. We discuss aging-related and extracardiac contributors to EI in HFpEF and provide the rationale for a transdisciplinary, "gero-centric" approach to advance our understanding of EI in HFpEF and identify promising new therapeutic targets. We also provide a framework for prioritizing future research, including developing a uniform, comprehensive approach to phenotypic characterization of HFpEF, elucidating key geroscience targets for treatment, and conducting proof-of-concept trials to modify these targets.
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